With nearly one hundred billion neurons, which are connected by trillions of synapses, the human brain is arguably the most complicated biological structure in the known universe. How the brain is built and functions remains one of the greatest mysteries in science and understanding what causes dysfunction of the brain in the case of disease poses one of the greatest challenges in medicine. The research in our laboratory aims towards contributing to a better understanding of this enigmatic organ in health and disease focusing on the molecular mechanisms underlying Alzheimer’s disease. We use a multi-disciplinary approach, combining single-cell genomics, genome engineering, pooled genetic screens, and computational analysis, to dissect the inner workings of brain cells and their dysfunction in Alzheimer’s disease.
A major focus of our research are the cellular and molecular mechanisms underlying Alzheimer’s disease. The goal is to understand why some people age in a healthy way without cognitive impairment and why others do not and develop dementia? We hope that understanding the underlying cellular and molecular root causes of Alzheimer’s disease will facilitate the development of protective or preventive therapeutic strategies that promote healthy aging.
