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TOP FIVE CITED PAPERS:
- Mathys H*, Davila-Velderrain J*, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Single- cell transcriptomic
analysis of Alzheimer’s disease. Nature. 2019 Jun;570(7761):332- PMID: 31042697 *these authors contributed equally to this work
- Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates
amyloid load and modifies microglia. Nature. 2016 Dec7; 540(7632):230-235. PMCID: PMC5656389
- Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, Kellis M. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature. 2015 Feb 19;518(7539):365-9.
PMCID: PMC4530583
- Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N. Mammalian
miRNA RISC recruits CAF1 and PABP to affect PABP- dependent deadenylation. Mol Cell. 2009 Sep 24;35(6):868-80. PMCID: PMC2803087
- Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH. Temporal Tracking of Microglia Activation in Neurodegeneration at Single- Cell Resolution. Cell Rep. 2017 Oct 10;21(2):366-380. PMCID: PMC5642107
PEER REVIEWED ARTICLES
- Eberle AB, Stalder L, Mathys H, Orozco RZ, Mühlemann O. Posttranscriptional gene regulation by spatial rearrangement of the 3′ untranslated region. PLoS Biol. 2008 Apr 29;6(4):e92.
PMCID: PMC2689704
- Zipprich JT, Bhattacharyya S, Mathys H, Filipowicz W. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA. 2009 May;15(5):781-93. PMCID: PMC2673060
- Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N. Mammalian
miRNA RISC recruits CAF1 and PABP to affect PABP- dependent deadenylation. Mol Cell. 2009 Sep 24;35(6):868-80. PMCID: PMC2803087
- Chekulaeva M. *, Mathys H. *, Zipprich J.T., Attig J., Colic M., Parker R., Filipowicz W. (2011) miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W- containing motifs. Nat Struct Mol Biol. 18(11):1218-26. PMCID: PMC3885283 *these authors contributed equally to this work
- Mathys H. *, Basquin J. *, Ozgur S., Czarnocki-Cieciura M., Bonneau F., Aartse A., Dziembowski A., Nowotny M., Conti E., Filipowicz W. (2014) Structural and Biochemical Insights to the Role of the CCR4-NOT Complex
and DDX6 ATPase in MicroRNA Repression. Mol Cell. 54(5):751-65. PMID: 24768538 *these authors contributed equally to this work
- Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, Kellis M. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease. Nature. 2015 Feb 19;518(7539):365-9.
PMCID: PMC4530583
- Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates
amyloid load and modifies microglia. Nature. 2016 Dec 7;540(7632):230-235. PMCID: PMC5656389
- Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, Hemberg M, De Jager PL, Ransohoff RM, Regev A, Tsai LH. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell Rep.
2017 Oct 10;21(2):366-380. PMCID: PMC5642107
- Singer AC, Martorell AJ, Douglas JM, Abdurrob F, Attokaren MK, Tipton J, Mathys H, Adaikkan C, Tsai LH. Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load. Nat Protoc.
2018 Aug;13(8):1850-1868. PMID: 30072722
- Mathys H*, Davila-Velderrain J*, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X, Martorell AJ, Ransohoff RM, Hafler BP, Bennett DA, Kellis M, Tsai LH. Single-cell transcriptomic
analysis of Alzheimer’s disease. Nature. 2019 Jun;570(7761):332-337. PMID: 31042697 *these authors contributed equally to this work
- Adaikkan C, Middleton SJ, Marco A, Pao PC, Mathys H, Kim DN, Gao F, Young JZ, Suk HJ, Boyden ES, McHugh TJ, Tsai LH. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. 2019 Jun 5;102(5):929-943.e8. PMID: 31076275
- Blanchard JW, Bula M, Davila-Velderrain J, Akay LA, Zhu L, Frank A, Victor MB, Bonner JM, Mathys H, Lin YT, Ko T, Bennett DA, Cam HP, Kellis M, Tsai LH. Reconstruction of the human blood-brain barrier in vitro reveals
a pathogenic mechanism of APOE4 in pericytes. Nat Med. 2020 Jun;26(6):952-963. PMID: 32514169
- Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou
Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states
via AKT hyperactivation. Sci Transl Med. 2021 Dec;13(622):eabe3947. PMID: 34851693
- Garcia FJ, Sun N, Lee H, Godlewski B, Mathys H, Galani K, Zhou B, Jiang X, Ng AP, Mantero J, Tsai LH, Bennett DA, Sahin M, Kellis M, Heiman M. Single-cell dissection of the human brain vasculature. Nature. 2022 Mar;603(7903):893-899. PMID: 35158371
- Colombo G, Cubero RJA, Kanari L, Venturino A, Schulz R, Scolamiero M, Agerberg J, Mathys H, Tsai LH, Chachólski W, Hess K, Siegert S. A tool for mapping microglial morphology, morphOMICs, reveals brain-region and
sex-dependent phenotypes. Nat Neurosci. 2022 Oct;25(10):1379-1393. doi: 10.1038/s41593-022-01167-6. Epub 2022 Sep 30. PMID: 36180790
PREPRINTS
- Yongjin Park, Liang He, Jose Davila-Velderrain, Lei Hou, Shahin Mohammadi, Hansruedi Mathys, Zhuyu Peng, David Bennett, Li-Huei Tsai, Manolis Kellis. Single-cell deconvolution of 3,000 post- mortem brain samples
for eQTL and GWAS dissection in mental disorders. BioRxiv 2021
- Jose Davila-Velderrain, Hansruedi Mathys, Shahin Mohammadi, Brad Ruzicka, Xueqiao Jiang, Ayesha Ng, David A Bennett, Li-Huei Tsai, Manolis Kellis. Single-cell anatomical analysis of human hippocampus and entorhinal
cortex uncovers early-stage molecular pathology in Alzheimer’s disease. BioRxiv 2021
- Na Sun, Leyla Anne Akay, Mitchell H Murdock, Yongjin Park, Adele Bubnys, Kyriaki Galani, Hansruedi Mathys, Xueqiao Jiang, Ayesha P Ng, David A Bennett, Li-Huei Tsai, Manolis Kellis. Single-cell multi-region dissection
of brain vasculature in Alzheimer′s Disease. BioRxiv 2022
- Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s Dementia. Maria Kousi, Carles A Boix, Yongjin P Park, Hansruedi Mathys, Samuel Sledzieski, Zhuyu Peng, David A Bennett,
Li-Huei Tsai, Manolis Kellis. BioRxiv 2022
